Laura and Isaac Perlmutter Cancer Center at NYU Langone and Technion-Israel Institute of Technology Officially Launch Global Cancer Research Initiative

 

 

Melanoma, Mesothelioma Are the Focus of First Joint Studies

 

Drug-carrying “nanoghosts” that battle melanoma and new treatments for malignant mesothelioma will be the focus of the first joint research projects led by NYU Langone Medical Center and the Technion-Israel Institute of Technology under a groundbreaking research initiative supported by noted philanthropists and NYU Langone Trustees Laura and Isaac Perlmutter.

 

NYU Langone and its Perlmutter Cancer Center – which the Perlmutters named in 2014 with a separate gift of more than $50 million – and the Technion established the new partnership last year to advance global collaboration in cancer research and therapeutics. The joint program is positioned to attract additional, world-class support from institutions and individuals dedicated to eradicating cancer through focused and efficient research.

 

The first $3 million of the Perlmutters’ $9 million donation to the two institutions is earmarked to finance six joint research projects. Co-investigators on each project will receive a two-year, $500,000 grant—$250,000 for each site. The remaining $6 million is designated to establish a state-of-the-art research facility on the Technion campus in Israel to support these and other research projects, primarily in the emerging field of cancer metabolomics, the systematic study of the unique chemical fingerprints that cellular processes leave behind. These processes are both affected by, and can influence, a variety of human diseases, including cancer. 

 

 

Examining a Novel Approach to Treat Metastatic Melanoma

 

In the first joint collaboration, NYU Langone and Technion researchers will test the ability of a nanotechnology based on stem cell “nanoghosts” to deliver to the brain a promising treatment for metastatic melanoma, skin cancer that has spread or metastasized, and is often incurable.

 

In earlier studies, researchers at the Technion took a stem cell, removed its contents, and then shaped a piece of the cell’s outer membrane into a vehicle to deliver treatments into the brain. The idea was to borrow the stem cell’s outer membrane ability to home in on cancer cells. As a fragment of the former stem cell’s membrane, the nanoghost encompasses particular mechanisms that slow it enough to traverse the barrier that filters blood flowing into the brain, and which keeps most drugs from entering.

 

The nanoghost’s cargo is a microRNA (miR), a stretch of genetic material that fine-tunes genetic messages by blocking the conversion of genes into proteins. First applied by NYU researchers to metastatic melanoma, miR-124a, in particular, blocks the expression of cancer-promoting genes. The joint team’s experiments will seek to determine the feasibility of encapsulating miR-124a in the nanoghost, and study how the vehicle reaches its target in mouse models of the disease.  

 

 

“Our studies should provide important information on nanoghosts’ general value as drug and gene carriers to the brain, and create potential for new treatment approaches against brain tumors and metastases,” said Professor Marcelle Machluf, PhD, head of the Laboratory for Cancer Drug Delivery & Cell Based Technologies at the Technion, and inventor of the nanoghost with her colleagues there. “The difficulty of delivering agents to the brain represents a major impediment to improving outcomes in patients suffering from brain tumors. Our state-of-the-art nanovehicle promises safer, simpler and more clinically relevant treatments than existing vehicles, which are comprised of polymers or synthetic vesicles which largely lack the ability to enter the brain and to target evolving and changing pathologies.”

 

“It is much harder to secure funding for this type of high risk, high reward research,” said Eva Hernando-Monge, PhD, associate professor in the Department of Pathology at NYU Langone, a member of the Perlmutter Cancer Center, and leader of the NYU team that first identified miR-124 as a suppressor of the growth of brain metastases. “The Perlmutters’ generous gift gives us the ability to be bold.”

 

Like the stem cells they are based on, nanoghosts are invisible to the immune system, which means they could potentially be made from donated stem cells, expanded to large numbers in the lab, and not just from the patient’s own supply. In the future, this could enable the stockpiling of nanoghost treatments used off the shelf without fear of immune reactions to treatments based on “foreign” cells.

 

  

New Approach to Mesothelioma

 

The second joint project will investigate whether an enzyme called heparanase can be used to diagnose and treat mesothelioma, a rare cancer that develops in the mesothelium, the protective lining of the lungs and other internal organs of the body. Malignant pleural mesothelioma (MPM), the most common form of the disease, often occurs after exposure to asbestos and is resistant to most therapies.

 

Heparanase was first identified as a treatment target in 2004 by a team led by Israel Vlodavsky, PhD, one of the project’s co-investigators and professor at the Rappaport Faculty of Medicine. Past studies found that patients with high levels of this enzyme in their tumors have lower survival rates after surgery, and that related tumors in mice respond to treatment with heparanase-inhibiting compounds.

 

The enzyme breaks up molecular chains of heparan sulfate, a building block of the scaffolds that give organs shape and support. Cancer cells use the enzyme to break down tissue barriers around a growing tumor, providing new pathways for the cancer to spread and for the building of blood vessels that supply tumors. In addition, breaking up extracellular matrices releases pro-growth proteins stored there to further drive disease. Furthermore, the joint team has developed the novel theory that heparanase secreted by tumor cells primes local microenvironments in a “vicious” cycle where inflammation and tumor growth drive each other.  

 

 

The co-investigators at NYU Langone -- led by Harvey I. Pass, MD, the Stephen E. Banner Professor of Thoracic Surgery and vice chair for research, Department of Cardiothoracic Surgery, at NYU Langone, also a member of its Perlmutter Cancer Center -- will use tissue samples from its Thoracic Oncology Archives to validate Dr. Vlodavsky’s findings in hopes of eventually evaluating the treatment potential of heparanase-inhibiting compounds in mesothelioma clinical trials. Dr. Pass has been collecting tissue samples from his surgical patients since 1989, when he was head of thoracic oncology at the National Cancer Institute (NCI). The collection now houses frozen specimens from more than 350 mesothelioma patients.

 

“This project, supported through the generosity of the Perlmutters, enables us to collaborate with one of the world’s leading experts on the role of heparanase in cancer, and is crucial in developing new strategies,” Dr. Pass says. "We hope that these experiments can be translated into applications for ongoing funding from the NCI, and enable Phase I trials with new therapeutics that influence heparanase pathways.”

 

“Our collaboration represents the first attempt to focus on heparanase as a major risk factor in mesothelioma and a valid target for the development of heparanase-inhibiting drugs,” Dr. Vlodavsky says. “In fact, applying a potent inhibitor of the heparanase enzyme we have already demonstrated a most prominent inhibition of tumor progression in mouse models of human mesothelioma, resulting in a pronounced extension of mouse survival. This joint effort provides an opportunity to make important strides in both our fundamental understanding of mesothelioma and in translating this knowledge into therapeutics.”

 

 

About The Technion-Israel Institute of Technology

 

The Technion-Israel Institute of Technology is a major source of the innovation and brainpower that drives the Israeli economy, and a key to Israel’s renowned as the world’s “Start-Up Nation.” Its three Nobel Prize winners exemplify academic excellence. Technion people, ideas and inventions make immeasurable contributions to the world including life-saving medicine, sustainable energy, computer science, water conservation and nanotechnology. The Joan and Irwin Jacobs Technion-Cornell Institute is a vital component of Cornell Tech, and a model for graduate applied science education that is expected to transform New York City’s economy.

 

 

About NYU Langone Medical Center

 

NYU Langone Medical Center, a world-class, patient-centered, integrated academic medical center, is one of the nation’s premier centers for excellence in clinical care, biomedical research, and medical education. Located in the heart of Manhattan, NYU Langone is composed of four hospitals—Tisch Hospital, its flagship acute care facility; Rusk Rehabilitation; the Hospital for Joint Diseases, the Medical Center’s dedicated inpatient orthopaedic hospital; and Hassenfeld Children’s Hospital, a comprehensive pediatric hospital supporting a full array of children’s health services across the Medical Center—plus the NYU School of Medicine, which since 1841 has trained thousands of physicians and scientists who have helped to shape the course of medical history. The Medical Center’s tri-fold mission to serve, teach, and discover is achieved 365 days a year through the seamless integration of a culture devoted to excellence in patient care, education, and research. For more information, go to www.NYULMC.org, and interact with us on Facebook, Twitter, and YouTube.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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A Record Number of 28 Israeli Companies Participating in DEFEXPO 2016

 

The Israeli pavilion at the DEFEXPO exhibition in India is the largest ever. Head of SIBAT: "Israel and India are working together to enhance cooperation in various technological fields"

 

Defense Ministry officials inaugurated the Israeli national pavilion at Defexpo in Goa, India, one of the most important defense exhibitions in the world. The opening ceremony of the Israeli pavilion was attended by the Director General of the Ministry of Defense, Maj. Gen. (res.) Dan Harel, Head of SIBAT, Brig. Gen. (res.) Michel Ben-Baruch, and CEO's of major defense industries.

 

This year, 28 Israeli defense industries and start-up companies will present a wide range of advanced technologies, most of which have been tested successfully on the battlefield. Among other things, Israeli companies will present sophisticated sensors, borders and sensitive facility protection systems, robotic systems, electro-optic systems for artillery and infantry, airborne satellite communications, fire control solutions, tactical medical equipment for the battlefield, and more.

 

Head of SIBAT, Brig. Gen. (res.) Michel Ben-Baruch said, "Israel and India are working together to enhance cooperation in various technological fields. India is a country with great capabilities. The large Israeli presence in the exhibition reflects our desire to strengthen the ties with Indian companies, and to increase the domestic production of advanced military technologies. A large part of the Israeli companies participating in the exhibition have been working closely with Indian companies, and we are confident that the collaboration will yield massive projects for Indian security forces."

 

Ben-Baruch added, "In the field of security, Israel and India face similar threats. The technological cooperation between the two countries will help us in the face of these threats, and will contribute to the economy of both countries."

 

The Israeli industries to exhibit in the national pavilion at DEFEXPO are Aeromaoz, Al Cielo, Astronautics, Beth-El industries, Camero, CI systems, Controp, Elbit Systems, Enercon, Persys Medical, IWI, Magal, Meprolight, MORE, Manomotion, Nimda, Noga-Einat, Opgal, Ophir Optronics, Orbit, PCB, Plasan, Rafael, Optica lab, SCD and Urdan.

 

Meanwhile, a large Israeli delegation of SIBAT will inaugurate the National Pavilion at FIDAE exhibition in Chile this week. This biennial event is the largest and most important aerospace exhibition in Latin America. Eleven leading Israeli defense industries in the Israeli pavilion will present a series of advanced technological solutions, most of which have had operational experience on the battlefield.

 

The Ministry of Defense stated that in recent years, the security market in Central and South America is one of the largest emerging markets in the world, both in the military field and in Border Protection and Homeland Security (HLS). More and more countries in Latin America are seeking cooperation with Western countries and leading defense industries. Changes in the geopolitical region also present many opportunities for the defense industry. Israeli defense companies specialize in the development of advanced technologies with proven operational experience, which can be adapted to the unique needs of each country. Therefore, these industries are considered particularly attractive to this market.

 

The Israeli industries to exhibit at the Israeli Pavilion at FIDAE are Elbit Systems, Rafael, IAI, IMI, IWI, Meprolight, Camero, VISION MAP, Controp, FAB and Beth-El industries.

 

 http://www.israeldefense.co.il/

 

 

 

 

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Under 30 EMEA: After Blowing Through $700 Million, Failed Better Place CEO Shai Agassi says that “If Not Willing To Fail, You Wont Succeed”

Tel Aviv, Israel--April 4, 2016– At the Forbes Under 30 Summit EMEA today, Israeli serial entrepreneur Shai Agassi, who raised (and subsequently lost) $700 million to accelerate the switchover to electric cars, outlined what he thinks will be the biggest disruption of the 21st century.

 

“At the end of the day the startups who are most successful are the ones who identify the waves way ahead of time….those who peddle after the wave has come don’t reach shore,” he said.

Led my moderator Maneet Ahuja, CNBC Hedge Fund Specialist & Producer on “Squawk Box,” panelists included some of the world’s top disruptors including Nikita Fahrenholz, Co-Founder & CEO ofBook A Tiger and Co-Founder ofDelivery Hero, in addition to Lisa Falzone, Co-Founder & CEO,Revel Systems. Panelists came together to discuss their secrets to success, how to deal with failure, as well as whether we are facing a new tech bubble.

 

Be willing to fail,” explained Agassi. “If you are not willing to fail you will not succeed. Sometimes, the difference between failure and success is so minuscule you won’t even notice it.”

You know you will make mistakes, stated Falzone, “but it’s about how fast you can recover from those mistakes. Speed is very important.”

When asked about the fear of failure, Fahrenholz stated, “You have to get comfortable with it. I’ve failed and failed- its part of what makes you human.  I never thought about the negative consequences of an experiment as much as the possible outcome.”

 

Falzone noted, “Failure is one of those concepts you have to overcome when you start your company.  I had to study it and overcome it to get the courage to start my company. I realized, I would rather be in the arena and fail then to be one of those cold timid souls and never be in the arena at all.”

At the conclusion of the panel, Ahuja asked serial entrepreneur Agassi as to whether another tech bubble was imminent. “This isn’t a bubble,” he explained, “its a tectonic plate shift and those who stay put will basically disappear.”

The Forbes Under 30 Summit EMEA brings together 600 greatest young entrepreneurs and game-changers from across the world, including 200 from the U.S., 200 from Europe and 200 from the Middle East and Africa, selected from the various Forbes 30 Under 30 lists.

 

# # #

About the Forbes Under 30 Summit

The Forbes Under 30 Summit franchise, one of the company’s most popular franchises, is an extension of Forbes magazine’s annual 30 Under 30 list. Attendees of the summit are culled from Forbes’ 30 Under 30 lists in the U.S., Europe and Israel. The Forbes Under 30 Summit EMEA will bring together 600 of the greatest young entrepreneurs and game-changers from America, Europe, the Middle East and Africa, for five days and nights of fostering world-changing ideas and collaborations. Under the theme “Co-Investment, Co-Creation and Co-Existence,” innovators, inventors, mentors and investors will focus on entrepreneurship and long-term, market-driven solutions to global problems, proving that growth is possible even in challenging times.

 

For more details on the Under 30 Summit, please visithttp://www.forbesconferences.com/event/2016-forbes-under-30-summit-israel/

 

On Twitter, follow #Under30Summit

 

About Forbes Media

Forbes Media is a global media, branding and technology company, with a focus on news and information about business, investing, technology, entrepreneurship, leadership and affluent lifestyles. The company publishes Forbes, Forbes Asia and Forbes Europe magazines as well as Forbes.com. The Forbes brand today reaches more than 80 million people worldwide with its business message each month through its magazines and 37 licensed local editions around the globe, websites, TV, conferences, research, social and mobile platforms. Forbes Media’s brand extensions include conferences, real estate, education, financial services and technology license agreements.

 

 

 

 

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1st International Digital Diplomacy Conference in Israel

 

For the first time in Israel - a Digital Diplomacy Conference hosted by the Ministry of Foreign Affairs and the Partner Institute for Internet Studies at the Tel-Aviv University brings together scholars and practitioners from around the world to investigate and advance the practice of diplomacy in the digital age and formulate a research agenda

 

The 1st International Digital Diplomacy Conference - the first of its kind in Israel - will examine the influence of the social networks and technologies on the activity of ministries of foreign affairs throughout the world. The conference will take place on 29-31 March 2016 at the Tel-Aviv University, with participants from 25 countries, including the US, UK, France, South Korea and Germany, as well as researchers from universities in the US, Europe and Israel in the fields of Diplomacy, Communications and the interaction among them.

 

The Israeli Ministry of Foreign Affairs has been highly active in the digital arena over the past few years, operating hundreds of accounts in various media and in about 50 languages, including Hebrew, English, Spanish, French, Arabic, Persian, Indonesian, Finnish and numerous others.

 

The conference will discuss the issue of "Technology at the Service of Diplomacy" and address questions, such as the use of social networks by ministries of foreign affairs to advance political goals; engagement in dialogue with on-line audiences; consular services to citizens in emergency situations; and country branding. In addition, the possibility of establishing an international digital network of ministries of foreign affairs will be explored for the first time.

 

These issues are being researched at the Department of Communications and the Partner Institute for Internet Studies at the Tel-Aviv University. The conference brings together diplomats who are active in the field and academic researchers, in a step intended to boost the development of digital diplomacy, and to create an exchange of views through which Israeli insights will be shared and each participant will be able to learn from the experience of other countries and from the insights of researchers in the field.

 

March 30 - 31, 2016, Israel

This two day international conference aims to bring together scholars and practitioners from around the world in order to investigate and advance the practice of diplomacy in the digital age as well as formulating a research agenda that will contribute to the study of Digital Diplomacy.

The conference shall be co-hosted by The Israeli Ministry of Foreign Affairs and the Partner Institute for Internet Studies at the University of Tel Aviv, and will include round-table discussions, expert panels and case - studies in which foreign ministries will be invited to share the insight they have gained. Recent years have seen Ministries of Foreign Affairs (MFA's), embassies and diplomats engage in social networking sites and according to the Twiplomacy website, there are now 228 MFA's and Foreign ministers active on twitter in addition to some 400 heads of state and governments. The conference will bring to the fore the many challenges facing the world of Digital Diplomacy ranging from the need to train diplomats in the art of social media engagement to identifying the means with which to evaluate its impact.

 

The conference will focus on the rise of a 'whole of government' approach to diplomacy as well as attempting to understand the relationship between the concepts of digital diplomacy, public diplomacy & nation branding.

 

 Contact: ddconf2016@mfa.gov.il 

 

 

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Over 60 leading women from across the world joined together last month for a panel discussion showcasing Israeli females in the lead.
Organized by The Israel Project (TIP) and the Embassy of Cyprus in Israel, the event served as a platform to discuss and understand the challenges and opportunities facing women in Israeli society in the modern age.
Among the panelists were popular journalist Judy Shalom Nir-Mozes. Former IDF commander Miri Eisin and Israeli Olympic athlete Maayan Davidovich.

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Prime Minister Benjamin Netanyahu, Greek Prime Minister Alexis Tsipras and Cypriot President Nicos Anastasiades, today (Thursday, 15 June 2017), in Thessaloniki, at the third trilateral summit, signed joint statements for the continued strengthening of relations.

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A senior delegation from Tanzania, headed by Dr. Aloyce Nzuki, Permanent Secretary Ministry for Natural Resources and Tourism, arrived in Israel for a series of meetings and events designed to increase cooperation with the Israeli tourist industry, and encourage Israeli tourism and investments to enchanted, exotic Tanzania.

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At a festive ceremony attended by Minister of Education Naftali Bennett, the Lauder Dormitory Building was inaugurated today at the Technion
state of the art building was donated to the Technion by World Jewish Congress President Ronald Lauder and his wife Jo Carole

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President Reuven Rivlin today (Wednesday) met at his residence in Jerusalem with United States Permanent Representative to the United Nations, Ambassador Nikki R. Haley.

President Rivlin welcomed her and said, “You are a dear friend of Israel. We appreciate your strong stand on the world’s most important stage, in support of the security of the people and the State of Israel. With your support we see the beginning of a new era. Israel is no longer alone at the UN. Israel is no longer the UN’s punching bag.”

He continued, “When I spoke at the UN on Holocaust Memorial Day, I said that the UN must learn from the lessons of the past, and stand up against hatred and racism. I said it must end its obsession with targeting Israel. Progress has been made. Israel’s standing at the UN has improved. But sadly, we have a long way to go. Both in holding to account, public statements made by officials, and in supporting regulation to reduce the ridiculous number of discussions and resolutions against Israel. This is also true in the Human Rights Council - which has been hijacked as a weapon against Israel - and in UNESCO, where they seek to rub out the history of the Jewish people.”

The President thanked the Ambassador for her great contribution to the State of Israel, and said, “Ambassador Haley, as the representative the US - Israel’s greatest and strongest ally - we appreciate very much your support of Israel, and all you do to stand up for the values of freedom and democracy which we share. Welcome to Israel, welcome to Jerusalem.”

Ambassador Haley thanked the President for his warm welcome and said, “Thank you Mr. President for taking the time to meet with us, it is an absolute thrill to be here in Israel, I so much appreciate the support we have received from the people of Israel. But I feel somewhat guilty because all I did at the United Nations was tell the truth. I have never taken kindly to bullies, and the UN has bullied Israel for a very long time, and we are not going to let that happen anymore. It is a new day for Israel in the United Nations. We just got back from Geneva, talking about the Human Rights Council and hopefully it will be a new day at the Human Rights Council when it comes to Israel.”

She concluded by saying she was greatly looking forward to her visit to Israel and said, “I am looking forward to taking in the history, the beauty, the tradition, and all that comes with the magic of Israel. Thank you very much for having me it is a pleasure to be here.”

Photo credit: Mark Neiman (GPO)

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A fundamentally agricultural holiday, Shavuot commemorates the custom of bringing offerings to the Holy Temple from the first fruits of the harvest and the first animals born to the flocks.

Shavuot, the Holiday of Weeks, is one of the three pilgrimage holidays, along with Pesach and Sukkot. These are the holidays on which the whole Jewish people would come to Jerusalem​ in ancient times, when the Holy Temple was there, and would offer animal and grain sacrifices.

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Tel Aviv Eat presents three evenings of tastings and workshops featuring the region’s leading restaurants and most prominent chefs. Entrance is free (including the chefs’ demonstrations), and tasting portions range in price from NIS 20-35. Doors open each evening at 18.00. There are several performance stages, live music, and stands selling beer.

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"Only when we remember the families who were torn apart from everyone they loved, who suffered that terrible darkness and evil, who had endured the unbearable horror of the Holocaust, only then can we prevent this agony from ever repeating." President Donald J. Trump Add a comment

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The Charles Bronfman Auditorium at Habima Square is one of the centerpieces of the Israeli arts and cultural scene, home to the Israel Philharmonic for the last 60 years. On Friday, May 19th, it was home to yet another historic event, with the dedication of the entrance hall to Miri Shitrit of blessed memory.

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  Prime Minister Benjamin Netanyahu and his wife Sara, today (Monday, 22 May 2017), at Ben-Gurion International Airport, welcomed US President Donald Trump and his wife Melania with an honor guard.

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The EU Commissioner for Research, Science and Innovation, Carlos Moedas, met Prime Minister Benjamin Netanyahu, Minister of Economy and Industry Eli Cohen, on 17 May to discuss Israel's
successful participation in Horizon 2020, European Union's research and innovation funding programme.

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On the eve of the Shavuot holiday, the Society for the Promotion of Tourism in Herzliya, in conjunction with the Grape Man, is hosting the White Summer White Wine Festival at the Herzliya Marina. The largest white wine festival in Israel will take place on the plaza of the marina on Wednesday and Thursday, May 24-25, 2017.

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President Reuven Rivlin this morning (Wednesday), met at his residence in Jerusalem with a delegation visiting Israel, made up of Jordanian sheikhs representing different tribes from across Jordanian society, from Irbid, Zarqa, and Amman. Also participating in the meeting were senior members of the, Middle East Department, of the Israeli Ministry of Foreign Affairs.

The delegation of sheikhs were visiting Israel for five days, during which they met with different faces from across Israeli society, deepening the understanding between the peoples.

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Just across the Ayalon Freeway from the Azrieli Center, in a mixed residential and office neighborhood, is a bistro barely one year old that is already making a name for itself.

In the words of chef-owner Daniella Berneman Fleishman herself, “On the border of Tel Aviv and Givatayim, I have opened a place that is the realization of a dream, combining my passion for hosting and love of food, where delicious food is served in a an atmosphere of home hospitality.”

Daniella has become popular with diverse audiences: workers from the adjacent office buildings during the day, families in the evening, and young people late at night. Parking on weekdays is only in paid parking garages, but there is plenty of free parking on evenings and weekends.

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The Archbishop of Canterbury, Justin Welby, visited the Peres Center for Peace and Innovation and met with Chemi Peres on Thursday (11.5) to promote interfaith relations and hear from Young Ambassadors for Peace

The Most Reverend Welby said: "Shimon Peres always supported and worked for peace initiatives. I am glad that we have people like you – Christian, Muslim, and Jewish, Palestinian and Israeli – who continue in this vision. We need you. You are our future. I will support you."

Chemi Peres: "You young people must not wait for an end to the conflict, but must trust yourselves and work together to move us forward."

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MARKET MOVERS article

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High 948.290 52wk Hight 988.250
Low 933.590 52wk Low 663.284
Vol 1.37M Avg Vol 1.60M
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