A new approach to stabilizing protein structures could be key to an efficient vaccine

 

Despite decades of malaria research, the disease still afflicts hundreds of millions and kills around half a million people each year – most of them children in tropical regions. Part of the problem is that the malaria parasite is a shape-shifter, making it hard to target. But another part of the problem is that even the parasite’s proteins that could be used as vaccines are unstable at tropical temperatures and require complicated, expensive cellular systems to produce them in large quantities. Unfortunately, the vaccines are most needed in areas where refrigeration is lacking and funds to buy vaccines are scarce. A new approach developed at the Weizmann Institute of Science, recently reported in Proceedings of the National Academy of Science (PNAS), could, in the future, lead to an inexpensive malaria vaccine that can be stored at room temperature.

 

The RH5 protein is one of the malaria parasite’s proteins that have been tested for use as a vaccine. This protein is used by the parasite to anchor itself to the red blood cells it infects. Using the protein as a vaccine alerts the immune system to the threat without causing disease, thus enabling it to mount a rapid response when the disease strikes, and to disrupt the parasite’s cycle of infection. Research student Adi Goldenzweig and Dr. Sarel Fleishman of the Institute’s Biomolecular Sciences Department decided to use the computer-based protein design tools they have been developing in Fleishman’s lab to improve the usefulness of this protein.

 

Based on software they have been creating for stabilizing protein structures, Goldenzweig developed a new program for “programming” proteins used in vaccines against infectious diseases. Such proteins, because they are under constant attack by the immune system, tend to mutate from generation to generation. So the program she developed uses all the known information on different configurations of the protein sequence in different versions of the parasite. “The parasite deceives the immune system by mutating its surface proteins. Paradoxically, the better the parasite is at evading the immune system, the more clues it leaves for us to use in designing a successful artificial protein,” she says.

 

The researchers sent the programmed artificial protein to a group in Oxford that specializes in developing a malaria vaccine. This group, led by Prof. Matthew Higgins and Simon Draper, soon had good news: The results showed that, in contrast with the natural ones, the programmed protein can be produced in simple, inexpensive cell cultures, and in large quantities. This could significantly lower production costs. In addition, it is stable at temperatures of up to 50o C, so it won’t need refrigeration. Best of all, in animal trials, the proteins provoked a protective immune response. “The method Adi developed is really general,” says Fleishman. “It has succeeded where others have failed, and because it is so easy to use, it might be applied to emerging infectious diseases like Zika or Ebola, when quick action can stop an epidemic from developing.”

 

Fleishman and his group are currently using their method to test a different strategy for treating malaria, based on targeting the RH5 protein itself and blocking its ability to mediate the contact between the parasite and human red blood cells.

Dr. Sarel Fleishman’s research is supported by the Rothschild Caesarea Foundation; Sam Switzer, Canada; and the European Research Council. Dr. Fleishman is the incumbent of the Martha S. Sagon Career Development Chair.

 

A Rusty Green Early Ocean?

Though they may seem rock solid, the ancient sedimentary rocks called iron formations – the world’s chief economic source of iron ore – were once dissolved in seawater. How did that iron go from a dissolved state to banded iron formations? Dr. Itay Halevy and his group in the Weizmann Institute of Science’s Earth and Planetary Sciences Department suggest that billions of years ago, the “rust” that formed in the seawater and sank to the ocean bed was green – an iron-based mineral that is rare on Earth today but might once have been relatively common.

 

We know there was dissolved iron in the early oceans, and this is a strong indication that Earth’s free oxygen (O2) concentrations were exceedingly low. Otherwise, the iron would have reacted with oxygen to form iron oxides, which are the rusty red deposits familiar to anyone who’s left a bike out in the rain. Today, says Halevy, iron is delivered from the land to the oceans as small insoluble oxide particles in rivers. But this mode of sedimentation only came about as free oxygen accumulated in Earth’s atmosphere, about 2.5 billion years ago. With almost no oxygen, the oceans were iron-rich, but that did not mean that iron remained dissolved in seawater indefinitely: It ultimately formed insoluble compounds with other elements and settled to the seabed to give rise to banded iron formations.

 

The idea that one of those insoluble compounds could be a rusty green mineral, says Halevy, occurred to him during his doctoral research, when he was trying to recreate the conditions on early Mars, including its rusty-red iron sediments. “I got some green stuff I didn’t recognize at first, which quickly turned orange when I exposed it to air. With a little more careful experimentation, I found that this was a mineral called green rust, which is extremely rare on Earth today, owing to its affinity for oxygen.” Today green rust quickly transforms into the familiar red rust, but with not much free oxygen around, Halevy reasoned, it could have been an important way for dissolved iron to form solid compounds and settle to the seafloor.

 

Support for these ideas comes from Sulawesi, Indonesia, where green rust forms today in iron-rich, oxygen-poor Lake Matano, thought to be similar to the seawater that existed during extended periods of Earth’s early history. To test his ideas in detail and explore their significance, Halevy set up experiments in which he and his team recreated, as closely as possible, the conditions of the ancient, oxygen-free, Precambrian ocean. They found that green rust not only forms under these conditions, but that when left to age, it transforms into the minerals found in Precambrian iron formations – a combination of iron-bearing oxides, carbonates and silicates.

 

Could green rust have been a main vehicle for settling iron out of seawater? Halevy and his team developed models to depict the iron cycle in Earth’s early oceans, including the possibility of green rust formation and competition with other mineral shuttles of iron to the seafloor. Their findings suggest that green rust was probably a major player in the iron cycle. The iron in the green rust later transformed into the minerals we can now observe in the geologic record. “Of course, it would have been one of several means of iron deposition, just as a number of different processes are involved in chemical sedimentation in the oceans today,” says Halevy. “But as far as we can tell, green rust should have delivered a substantial proportion of iron to the very early ocean sediments.”

 

Dr. Itay Halevy’s research is supported by the Helen Kimmel Center for Planetary Science; the Deloro Institute for Advanced Research in Space and Optics; and the Wolfson Family Charitable Trust. Dr. Halevy is the incumbent of the Anna and Maurice Boukstein Career Development Chair in Perpetuity.

 

Uncovering the Secrets of White Cell Power

 

White blood cells push their way through barriers to get to infection sites

 

One of the mysteries of the living body is the movement of cells – not just in the blood, but through cellular and other barriers. New research in the Weizmann Institute of Science has shed light on the subject, especially on the movement of immune cells that race to the sites of infection and inflammation. The study revealed that these cells – white blood cells – actively open large gaps in the internal lining of the blood vessels, so they can exit through the vessel walls and rapidly get to areas of infection.

 

Prof. Ronen Alon and his group in the Weizmann Institute’s Immunology Department discovered how various white blood cells push their way through the lining of the blood vessels when they reach their particular “exit ramps.” Using their nuclei to exert force, they insert themselves between – as well as into – the cells in the vessel walls called endothelial cells. Dismantling structural filaments within the cytoskeletons – the internal skeletons – of the endothelial cells creates the large holes – several microns in diameter.

 

Alon explains that the nucleus is the largest, most rigid structure in the cell. When driven by motors specifically engaged for this function, is tough enough to push through the barrier imposed by the blood vessel walls.  

 

The scientists tracked the cytoskeletons of endothelial cells as they were crossed by immune cells in real time, the behavior of the nuclei of various white blood cells during active squeezing and the fate of the various types of actin fibers that make up the endothelial cell skeletons. The researchers used a number of methods, including fluorescence and electron microscopy, in collaboration with Dr. Eugenia Klein of the Microscopy Unit; a unique system in Alon’s lab for simulating blood vessels in a test tube; and in vivo imaging with Prof. Sussan Nourshargh of Queen Mary University of London. The results of this research, conducted in Alon’s lab by research students Sagi Barzilai and Francesco Roncato and postdoctoral fellow Dr. Sandeep Kumar Yadav, were recently reported in Cell Reports.

 

Common wisdom in this field had held that the endothelial cells must help immune cells squeeze through by contracting themselves like small muscles, but the present study found no evidence for such contraction-based help. Alon says: “Our study shows that the endothelial cells, which were thought to be dynamic assistants in this process of crossing of blood vessel walls, are really more responders to the ‘physical work’ invested by the white blood cell motors and nuclei in generating gaps and crossing through blood vessels.”

 

Significance for cancer research

In addition to increasing the basic understanding of how the various arms of the immune system reach their sites of differentiation and activity, these findings may aid in cancer research. “We believe that small subsets of metastatic tumor cells have the ability to adopt the mechanisms used by immune cells to exit the blood vessels into the lungs, the bone marrow, the brain and other organs. If this is true, we might be able to identify these subsets and target them before these cells leave their original tumor sites and invade distant organs,” says Alon.

 

Prof. Ronen Alon’s research is supported by the Herbert L. Janowsky Lung Cancer Research Fund; Mr. and Mrs. William Glied, Canada; and Carol A. Milett, Aventura, FL. Prof. Alon is the incumbent of the Linda Jacobs Professorial Chair in Immune and Stem Cell Research.

 

 The Weizmann Institute of Science is one of the world’s leading multidisciplinary research institutions. Comprising five faculties, 17 departments, a graduate school and 50 multidisciplinary centers, hundreds of scientists, laboratory technicians and research students work on the Institute's lushly landscaped campus, embarking daily on fascinating journeys into the unknown, seeking to improve our understanding of nature and our place within it.

 

http://wis-wander.weizmann.ac.il/

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https://www.instagram.com/weizmanninstitute

 

Photo : by   “thinkstock”.    provided by  Weizmann Department of Media Relations

 

 

 

 

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Israeli Prime Minister Benjamin Netanyahu will be the keynote speaker at the second-largest exhibition of cyber technologies worldwide, with attendees including state leaders from around the world, global cyber security executives and investors. Mr. Chuck Robbins, CEO, Cisco, will be among the world-renowned speakers participating.

 

A variety of cyber-dedicated professional presentations, events and panels with experts from around the world regarding diverse topics such as international collaboration between national law enforcement authorities and the field's present challenges will be held at the conference, in addition to a hacker zone, startup competition and more.  

 

January 30th -February 1st 2017, Israel Trade Fairs & Convention Center, Pavilion 2

 

 

 

 

The Cybertech 2017 Conference, held for the fourth year in Israel at Pavilion 2 of the Israel Trade Fairs & Convention Center on January 30th - February 1st is the second largest conference and exhibition of cyber technologies in the world. Cybertech, bringing together leading investors, entrepreneurs and cyber companies, will consist of a conference with prominent international speakers in the field of cyber security, as well as an exhibition hosting over 250 companies and 100 startups that will present innovative problem-solving strategies and solutions to challenges relevant for a wide range of sectors.

 

Hundreds of foreign delegations, representatives of multinational corporations and foreign investors will travel to Israel to gain exposure to the latest innovations in cyber technologies, and take part in the conference and mega exhibition. Israeli Prime Minister Benjamin Netanyahu, who launched the Israel National Cyber authority devoted entirely to cyberwarfare, will open the Cybertech Conference as the keynote speaker.

 

Other opening plenary speakers alongside Prime Minister Benjamin Netanyahu will include Gov. Rick Snyder, Governor of the State of Michigan as well as Israeli and international cyber industry experts & executives from leading companies such as Cisco, HP, IBM, Checkpoint and Matrix.

 

The CyberTech Conference will host other prominent speakers, including Mr. Chuck Robbins, CEO, Cisco,  Dr. Yossi Vardi, Conference Chairman, Chief Superintendent Meir Hayun, Head of National Cybercrime Unit, Israel Police, Dr. Eviatar Matania, Head of the National Cyber Bureau in the Prime Minister office of Israel, Mr. Yair Frank, Government CIO, Head of ICT Authority, Prime Minister Office of Israel, Mr. Avi Hasson, Chief Scientist, Ministry of Economy & Industry,Mr. Luigi Rebuffi, CEO & founder, EOS; Secretary General, ECSO, DPM., Peter Pellegrini, Deputy Prime Minister, Slovakia, Dr. Dorit Dor, VP of Products, Check Point Software Technologies, Mr. Gerard Brady, Managing Director, CISO, Morgan Stanley, USA, and many others.

 

The event will provide a unique platform for discussion about the latest cyber-related technological developments through panel discussions such as challenges and solutions for the cyber industry, international collaboration between law enforcement authorities around the world, cognitive computing issues, and the future of cyber security for the fintech industry. Furthermore, Cybertech will also host a variety of other events and complexes dedicated to current issues and breakthroughs, such as an Israeli startup pavilion with 100 different presentations by cyber companies, a hacker zone which will include an IoT hacking challenge and unique cyber-themed escape rooms, a Start Up competition and more.

 

In addition to the unique opportunity to discover the latest innovations in the local and global cyber community, Cybertech presents problem-solving strategies and solutions to challenges for a wide range of sectors including finance, defense, transportation, utilities, R&D, energy, manufacturing, service sectors, health, media, government, and more.

The event will allow businesses, startups, investors, government officials, military personnel, ambassadors and exhibition visitors to focus on networking, strengthening existing alliances, and forming new ones.

 

 

Link to the conference Site| Link to the full speakers list | Link to the Conference program

 

Link to Israeli Start Up Pavilion| Link to registration for the Start Up competition

 

Photos Gilad Kavaranchik

 

 

 

 

 

 

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Forbes Announces First Round of Speakers for 2017 Forbes Under 30 Summit EMEA



 

 

 

 

Speakers for Forbes’ Under 30 Summit EMEA include Sean Rad, Cofounder and Chairman, Tinder; Yossi Vardi, Internet Entrepreneur; Teddy Sagi, Founder of PlayTech, Market Tech and  SafeCharge; Steven Izen, Founder & CEO, Lokai; and Farah Abdi, Somali Refugee, Author, Blogger and Human Rights Activist


750 Young Entrepreneurial Game Changers and Legendary Mentors Are Expected to Gather in

Jerusalem and Tel Aviv, April 2-6, 2017

TEL AVIV (January 26, 2017) – Forbes announced today the first round of speakers and participants for the second Under 30 Summit EMEA (Europe, Middle East and Africa), which will take place in Tel Aviv and Jerusalem, April 2-6, under the theme “Innovation, Exploration, and Inspiration.”  For the summit, an invitation-only event, Forbes is expected to bring together over 750 of some of the world’s most influential young entrepreneurs -- 250 from the U.S., 250 from Europe and 250 from Israel, as culled from Forbes’ 30 Under 30 lists.  The speakers announced today include:

  • Sean Rad, Cofounder and Chairman, Tinder (U.S.)

  • Yossi Vardi, Internet Entrepreneur (Israel) 

  • Teddy Sagi, Businessman and Entrepreneur, Founder of PlayTech, Market Tech and  SafeCharge

  • Steven Izen, Founder and CEO, Lokai (U.S.)

  • Farah Abdi, Somali Refugee, Author, Blogger & Human Rights Activist (Germany)

  • Obinwanne Okeke, Chairman and CEO, Invictus (Nigeria)

  • Lawrence Brand, Founder, Porterlight Bicycles (U.K.)

  • Joséphine Goube, CEO, Techfugees (U.K.)

  • Sofia Hmich, Founder, Future Positive Capital (U.K.)

  • Anne-Marie Imafidon MBE, CEO and ‘Head Stemette’, Stemettes (U.K.)

  • Netanel Rubin, CEO, Vaultra (Israel)


For more information on the summit, please visit:

www.forbesconferences.com/event/2017-forbes-under-30-summit-jerusalem-tel-aviv/.


Building on last year’s successful entrepreneur-driven summit and cultural immersion, Forbes is expanding its celebration of innovation and startups.  For five days, innovators, inventors, pioneers, mentors and investors will focus on breakthrough ideas that tackle the most intractable problems facing our society and the planet.


Forbes will feature -- as part of the summit’s agenda, panels, interviews, performances, product demos and keynote addresses, showcasing the most cutting-edge innovators and disruptors, and will provide mentorship from successful business leaders. The conversation will focus on using innovation to reimagine humanity.  At the event, participants will hear from visionaries -- entrepreneurs, artists, activists and inventors -- shaping the future in powerful ways. 


“As these innovators explore the intersection of Big Data, smart design, AI, robotics, virtual and augmented reality and other accelerating tech trends, participants in our summit will realize an evident truth: We have the tools and technologies to create a better world, if we can muster the comity and the will,” said Randall Lane, Editor of Forbes magazine and creator of Forbes’ Under 30 franchise.


The summit will offer rich cultural-immersion activities and a unique global-networking environment.  Forbes 30 Under 30 Summit attendees will also have the opportunity to mentor and inspire the next generation of young superstar entrepreneurs in the local communities of Israel.  


  • The summit will kick off with a welcome party on the shores of the Mediterranean.

  • On April 3, participants will gather in Tel Aviv for a day of content focused on “Innovation,” while enjoying access to an entire Forbes Under 30 Village with joined booths, displays and demonstrations.

  • April 4th will be devoted to “Exploration” and cultural immersion. Rothschild Boulevard will be transformed into an Open House, as summit participants will be able to explore and join tours, including a guided tour of the Old City in Jerusalem.

  • April 5th will focus on “Inspiration -- Making a Difference, Healing the World.”  Participants will visit sites across Greater Israel to cultivate conversations about achieving actionable solutions. The day will end with the Forbes Under 30 Music Festival, featuring acts from across Israel, Europe and America.

  • On April 6, the summit will conclude with a day of inspiration and reflection, starting at sunrise at Masada and the Dead Sea.


The Presenting Sponsors for the summit are Lokai and Market Tech.


Forbes’ Under 30 franchise is a global multichannel platform that comprises 30 Under 30 lists featuring young global game changers and published in print and online all over the world; live summits in the U.S., Asia and Israel; an Under 30 channel on Forbes.com; and a Forbes Under 30 app. To access Forbes magazine’s 2017 30 Under 30 U.S. list, please visit www.forbes.com/30under30.


About Forbes Media:

Forbes Media is a global media, branding and technology company, with a focus on news and information about business, investing, technology, entrepreneurship, leadership and affluent lifestyles. The company publishes Forbes and Forbes Asia as well as Forbes.com.  The Forbes brand today reaches more than 94 million people worldwide with its business message each month through its magazines and 38 licensed local editions around the globe, Forbes.com, TV, conferences, research, social and mobile platforms. Forbes Media’s brand extensions include conferences, real estate, education, financial services and technology license agreements. 


About Lokai:

Lokai is a socially responsible lifestyle brand that represents the importance of finding balance along life’s journey. Steven Izen founded the company in 2013, on the heels of a deeply emotional and transformative experience. Realizing that life is a cycle of highs and lows, he grew to appreciate the importance of remaining both humble and hopeful. The company infuses its trademark bracelets with elements sourced from the highest and lowest points on Earth -- water from Mt. Everest and mud from the Dead Sea. The Lokai lifestyle is devoted to finding balance, sharing success during life’s peaks and gaining perspective during lows. Lokai supports this message by donating 10% of net profits to various charitable organizations. Since launching, Lokai is sold in over 160 countries.

Please visit www.lokai.com for more information. www.Instagram.com/livelokai | www.Twitter.com/livelokai | www.Facebook.com/livelokai


About Market Tech:

Market Tech is an LSE-listed property company that owns, manages and is developing a unique 16 acre estate (valued at £1 billion as of September 30, 2016) of office, retail, leisure and living spaces centred around the iconic Camden Markets, and supported by three e-commerce businesses, referred to as Market Tech Digital. These are Stucco Media, an e-commerce marketing platform, Glispa; a Berlin-based mobile marketing business and Fiver; a B2C online fashion retailer. www.market-tech.com

 
 
 
 
 
 
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An important milestone in the establishment of GTIIT - Guangdong Technion Israel Institute of Technology - was recorded with the official approval by the Ministry of Education of the People’s Republic of China. The Ministry confirmed that cooperation with Technion is consistent with the strategic goal of the Chinese Government: the establishment of world-class research universities; as well as with the regional strategy of innovation-based development.

 

The Chinese National Program for Medium- and Long-Term Educational Reform and Development is intended, inter alia, to promote the establishment of superior foreign educational resources and to establish several model Chinese-foreign universities in China, based on cooperation with other countries.

 

Approval for GTIIT was given exactly one year after the cornerstone laying ceremony for the new campus: a ceremony which was attended by about 5,000 guests, including the late ninth President of the State of Israel, Shimon Peres z”l. At that event, Peres said that “the establishment of a Technion campus in China is one more proof that Israeli innovation is breaking down geographic borders.”

 

The establishment of Guangdong Technion - the first Israeli university in China - is a dramatic and unprecedented event in Israel-China relations. Israel’s Ambassador to China Matan Vilnai said: “The opening of the Technion branch in China is the most important project in Israel-China relations during my term in office. This project, which focuses on education, is an important asset to China and Israel and hence its great importance. We have worked hard to obtain approval and I am pleased that it has been granted.”

 

“This is a courageous and important partnership which represents a historic step in Israel-China relations,” said Technion President Prof. Peretz Lavie. “This partnership, which combines the spirit of Israeli innovation with the power of China, will benefit all parties - the Technion and the University of Shantou, Israel and China - and will give a significant boost to the Chinese education system. The outcomes of this historic project will affect the whole of humanity.”

 

“I’m glad we did it,” said the Mayor of Shantou, Liu Xiaotao. “I would like to thank Technion President Prof. Peretz Lavie and professors from the Technion for their efforts and dedication. On behalf of the 5.5 million residents of Shantou, I would like to thank you for this important project.”

 

Guangdong Technion, situated near the Shantou University campus, will be a high quality, innovative and research-oriented university. In the future, an innovation center will be built near it, and will serve as a foothold for Israeli companies to crack key markets in the U.S. and China. This project is made possible thanks to the cooperation between China’s Shantou University, Guangdong Provincial Government, Shantou Municipal Government and the Technion. The project leader on behalf of the Technion is Prof. Paul Feigin, Assistant to the President for Strategic Projects.

 

According to the letter of approval from the Government of China, “GTIIT is a beneficial attempt to build a high standard and exemplary Sino-foreign co-running university. Guangdong Government shall offer guidance and take advantages of subjects and research provided by both sides, integrate educational resources, innovate methods of cultivating talents, classifying subjects and courses, and managing schools. It will promote Sino-Israeli educational cooperation and exchange, and contribute to our educational reform. GTIIT shall progressively carry out the master and doctoral programs by learning from Technion’s advanced experience in the way of independent admission according to the Sino-Foreign Cooperative Education Provision and its concrete measures. Masters and PhD degree certificates will be issued by Technion. “GTIIT shall strive for economic growth and social development based on the areas where Technion excels and in accordance with the environmental challenges faced by China.

 

The new university is headed by GTIIT Chancellor Mr. Li Jiange and Vice Chancellor Research Professor Aaron Ciechanover from the Technion. “The Government’s approval of the establishment of GTIIT has brought us much joy and confidence,” said Chancellor Mr. Li Jiange. “As an ancient Chinese saying goes, ‘A journey of a thousand miles begins with a single step.’  Now we have achieved the first step of success, we still have a long way to go. To build GTIIT into a world-class university, we need to recruit the elite faculties, and we are willing to pay them with the most attractive salaries.”

 

“The granting of approval by the Government of China is a moment of great hope for all of us,” said Prof. Ciechanover, winner of the Nobel Prize in Chemistry for 2004. “This is an initiative that will combine the diligence and determination typical of China with the extensive experience of the Technion in training scientists and engineers, and in turning scientific discoveries into developments that are beneficial to mankind.”

 

According to the letter of approval from the Government of China, GTIIT will have 2,960 students in the initial stage (from 2017 to 2026), including 300 postgraduates, and 5,000 in the long term, including 1,000 postgraduates. Guangdong Technion’s first undergraduate programs are Chemical Engineering, Biotechnology and Food Engineering, and Materials Engineering. Its graduate programs are Chemical Engineering, Materials Engineering, Food Engineering, Environmental Engineering, Mathematics, Physics, Chemistry and Biology. Its doctoral programs will also be in these disciplines . 

 

The cooperation between the Technion and Guangdong Province has already led to several other agreements, including a memorandum of understanding for scientific cooperation between the State of Israel and Guangdong Province, economic cooperation agreements and a twin city agreement between the cities of Haifa and Shantou. The first academic school year at Guangdong Technion is scheduled to begin in October 2017, with 300 students will first complete a preparatory period starting in August.

 

Photo Left to right: Shantou University Provost Prof. Gu Peihua, GTIIT Chancellor Mr. Li Jiange, Shantou Mayor Liu Xiaotao, Technion President Prof. Peretz Lavie, Assistant to the President for Strategic Projects Prof. Paul Feigin, and Shantou University Vice President Prof. Lin Danming

 

Credit: Government of the Guangdong Province

 

 

 

 

 

 

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Over 60 leading women from across the world joined together last month for a panel discussion showcasing Israeli females in the lead.
Organized by The Israel Project (TIP) and the Embassy of Cyprus in Israel, the event served as a platform to discuss and understand the challenges and opportunities facing women in Israeli society in the modern age.
Among the panelists were popular journalist Judy Shalom Nir-Mozes. Former IDF commander Miri Eisin and Israeli Olympic athlete Maayan Davidovich.

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Prime Minister Benjamin Netanyahu, Greek Prime Minister Alexis Tsipras and Cypriot President Nicos Anastasiades, today (Thursday, 15 June 2017), in Thessaloniki, at the third trilateral summit, signed joint statements for the continued strengthening of relations.

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A senior delegation from Tanzania, headed by Dr. Aloyce Nzuki, Permanent Secretary Ministry for Natural Resources and Tourism, arrived in Israel for a series of meetings and events designed to increase cooperation with the Israeli tourist industry, and encourage Israeli tourism and investments to enchanted, exotic Tanzania.

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At a festive ceremony attended by Minister of Education Naftali Bennett, the Lauder Dormitory Building was inaugurated today at the Technion
state of the art building was donated to the Technion by World Jewish Congress President Ronald Lauder and his wife Jo Carole

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President Reuven Rivlin today (Wednesday) met at his residence in Jerusalem with United States Permanent Representative to the United Nations, Ambassador Nikki R. Haley.

President Rivlin welcomed her and said, “You are a dear friend of Israel. We appreciate your strong stand on the world’s most important stage, in support of the security of the people and the State of Israel. With your support we see the beginning of a new era. Israel is no longer alone at the UN. Israel is no longer the UN’s punching bag.”

He continued, “When I spoke at the UN on Holocaust Memorial Day, I said that the UN must learn from the lessons of the past, and stand up against hatred and racism. I said it must end its obsession with targeting Israel. Progress has been made. Israel’s standing at the UN has improved. But sadly, we have a long way to go. Both in holding to account, public statements made by officials, and in supporting regulation to reduce the ridiculous number of discussions and resolutions against Israel. This is also true in the Human Rights Council - which has been hijacked as a weapon against Israel - and in UNESCO, where they seek to rub out the history of the Jewish people.”

The President thanked the Ambassador for her great contribution to the State of Israel, and said, “Ambassador Haley, as the representative the US - Israel’s greatest and strongest ally - we appreciate very much your support of Israel, and all you do to stand up for the values of freedom and democracy which we share. Welcome to Israel, welcome to Jerusalem.”

Ambassador Haley thanked the President for his warm welcome and said, “Thank you Mr. President for taking the time to meet with us, it is an absolute thrill to be here in Israel, I so much appreciate the support we have received from the people of Israel. But I feel somewhat guilty because all I did at the United Nations was tell the truth. I have never taken kindly to bullies, and the UN has bullied Israel for a very long time, and we are not going to let that happen anymore. It is a new day for Israel in the United Nations. We just got back from Geneva, talking about the Human Rights Council and hopefully it will be a new day at the Human Rights Council when it comes to Israel.”

She concluded by saying she was greatly looking forward to her visit to Israel and said, “I am looking forward to taking in the history, the beauty, the tradition, and all that comes with the magic of Israel. Thank you very much for having me it is a pleasure to be here.”

Photo credit: Mark Neiman (GPO)

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A fundamentally agricultural holiday, Shavuot commemorates the custom of bringing offerings to the Holy Temple from the first fruits of the harvest and the first animals born to the flocks.

Shavuot, the Holiday of Weeks, is one of the three pilgrimage holidays, along with Pesach and Sukkot. These are the holidays on which the whole Jewish people would come to Jerusalem​ in ancient times, when the Holy Temple was there, and would offer animal and grain sacrifices.

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Tel Aviv Eat presents three evenings of tastings and workshops featuring the region’s leading restaurants and most prominent chefs. Entrance is free (including the chefs’ demonstrations), and tasting portions range in price from NIS 20-35. Doors open each evening at 18.00. There are several performance stages, live music, and stands selling beer.

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"Only when we remember the families who were torn apart from everyone they loved, who suffered that terrible darkness and evil, who had endured the unbearable horror of the Holocaust, only then can we prevent this agony from ever repeating." President Donald J. Trump Add a comment

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The Charles Bronfman Auditorium at Habima Square is one of the centerpieces of the Israeli arts and cultural scene, home to the Israel Philharmonic for the last 60 years. On Friday, May 19th, it was home to yet another historic event, with the dedication of the entrance hall to Miri Shitrit of blessed memory.

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  Prime Minister Benjamin Netanyahu and his wife Sara, today (Monday, 22 May 2017), at Ben-Gurion International Airport, welcomed US President Donald Trump and his wife Melania with an honor guard.

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The EU Commissioner for Research, Science and Innovation, Carlos Moedas, met Prime Minister Benjamin Netanyahu, Minister of Economy and Industry Eli Cohen, on 17 May to discuss Israel's
successful participation in Horizon 2020, European Union's research and innovation funding programme.

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On the eve of the Shavuot holiday, the Society for the Promotion of Tourism in Herzliya, in conjunction with the Grape Man, is hosting the White Summer White Wine Festival at the Herzliya Marina. The largest white wine festival in Israel will take place on the plaza of the marina on Wednesday and Thursday, May 24-25, 2017.

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President Reuven Rivlin this morning (Wednesday), met at his residence in Jerusalem with a delegation visiting Israel, made up of Jordanian sheikhs representing different tribes from across Jordanian society, from Irbid, Zarqa, and Amman. Also participating in the meeting were senior members of the, Middle East Department, of the Israeli Ministry of Foreign Affairs.

The delegation of sheikhs were visiting Israel for five days, during which they met with different faces from across Israeli society, deepening the understanding between the peoples.

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Just across the Ayalon Freeway from the Azrieli Center, in a mixed residential and office neighborhood, is a bistro barely one year old that is already making a name for itself.

In the words of chef-owner Daniella Berneman Fleishman herself, “On the border of Tel Aviv and Givatayim, I have opened a place that is the realization of a dream, combining my passion for hosting and love of food, where delicious food is served in a an atmosphere of home hospitality.”

Daniella has become popular with diverse audiences: workers from the adjacent office buildings during the day, families in the evening, and young people late at night. Parking on weekdays is only in paid parking garages, but there is plenty of free parking on evenings and weekends.

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The Archbishop of Canterbury, Justin Welby, visited the Peres Center for Peace and Innovation and met with Chemi Peres on Thursday (11.5) to promote interfaith relations and hear from Young Ambassadors for Peace

The Most Reverend Welby said: "Shimon Peres always supported and worked for peace initiatives. I am glad that we have people like you – Christian, Muslim, and Jewish, Palestinian and Israeli – who continue in this vision. We need you. You are our future. I will support you."

Chemi Peres: "You young people must not wait for an end to the conflict, but must trust yourselves and work together to move us forward."

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Currency Exchange Rate

MARKET MOVERS

NMS : YHOO - 01 Jan,
-52.58 (-100.00%) After Hours:
Open Mktcap
High 52wk Hight
Low 52wk Low
Vol 0 Avg Vol
Eps 0.71 P/e
Currency:

Alphabet Inc.

NMS : GOOG - 27 Jun, 1:36pm
934.646
-17.624 (-1.851%) After Hours:
Open 942.460 Mktcap 646.54B
High 948.290 52wk Hight 988.250
Low 933.590 52wk Low 663.284
Vol 1.37M Avg Vol 1.60M
Eps 33.910 P/e 31.583
Currency: USD

Apple Inc.

NMS : AAPL - 27 Jun, 1:36pm
145.02
-0.80 (-0.55%) After Hours:
Open 145.01 Mktcap 756.11B
High 146.16 52wk Hight 156.65
Low 144.61 52wk Low 91.50
Vol 11.99M Avg Vol 27.24M
Eps 8.94 P/e 17.01
Currency: USD

Weather

Jerusalem Israel Clear (night), 21 °C
Current Conditions
Sunrise: 5:36 am   |   Sunset: 7:49 pm
47%     4.9 m/s     31.350 atm
Forecast
Wed Low: 20 °C High: 32 °C
Thu Low: 18 °C High: 31 °C
Fri Low: 20 °C High: 33 °C
Sat Low: 21 °C High: 35 °C
Sun Low: 22 °C High: 37 °C
Mon Low: 23 °C High: 37 °C
Tue Low: 23 °C High: 35 °C
Wed Low: 21 °C High: 31 °C
Thu Low: 19 °C High: 31 °C
Fri Low: 20 °C High: 31 °C

MARKET MOVERS article

NMS : YHOO - 01 Jan,
-52.58 (-100.00%) After Hours:
Open Mktcap
High 52wk Hight
Low 52wk Low
Vol 0 Avg Vol
Eps 0.71 P/e
Currency:

Alphabet Inc.

NMS : GOOG - 26 Jun, 4:00pm
952.27
-13.32 (-1.38%) After Hours:
Open 969.90 Mktcap 658.73B
High 973.31 52wk Hight 988.25
Low 950.79 52wk Low 663.28
Vol 1.60M Avg Vol 1.60M
Eps 33.91 P/e 32.18
Currency: USD

Apple Inc.

NMS : AAPL - 26 Jun, 4:00pm
145.82
-0.46 (-0.31%) After Hours:
Open 147.17 Mktcap 760.28B
High 148.28 52wk Hight 156.65
Low 145.38 52wk Low 91.50
Vol 25.69M Avg Vol 27.24M
Eps 8.94 P/e 17.11
Currency: USD